Kazuo Umemura Selected Research

Thrombosis (Thrombus)

1/2022	In vitro analysis of mechanism of pulsed-laser thrombolysis.
1/2015	Vascular Smooth Muscle Cells Stimulate Platelets and Facilitate Thrombus Formation through Platelet CLEC-2: Implications in Atherothrombosis.
8/2010	Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets.
10/2009	GIF-0173 protects against cerebral infarction through DP1 receptor activation.
11/2004	Neuroprotective effects of ONO-1924H, an inhibitor of poly ADP-ribose polymerase (PARP), on cytotoxicity of PC12 cells and ischemic cerebral damage.
4/2003	Inhibitory effects of total flavones of Hippophae Rhamnoides L on thrombosis in mouse femoral artery and in vitro platelet aggregation.
4/2002	A novel MCA occlusion model of photothrombotic ischemia with cyclic flow reductions: development of cerebral hemorrhage induced by heparin.

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Kazuo Umemura Research Topics

Disease

11	Stroke (Strokes) 05/2018 - 10/2002
9	Hemorrhage 03/2023 - 04/2002
8	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 12/2015 - 06/2002
7	Thrombosis (Thrombus) 01/2022 - 04/2002
6	Ischemic Stroke 03/2023 - 11/2004
6	Infections 01/2020 - 09/2011
5	Atherosclerosis 07/2022 - 01/2017
5	Cerebral Infarction 01/2020 - 08/2002
5	Ischemia 01/2011 - 04/2002
4	Rupture 01/2024 - 02/2002
4	Inflammation (Inflammations) 06/2023 - 03/2009
4	Brain Ischemia (Cerebral Ischemia) 01/2016 - 04/2004
3	Intracranial Aneurysm (Cerebral Aneurysm) 01/2024 - 01/2018
3	Aneurysm (Aneurysms) 06/2023 - 09/2015
3	Hypercholesterolemia 10/2022 - 12/2021
3	Atherosclerotic Plaque (Atheroma) 04/2018 - 11/2014
3	Reperfusion Injury 01/2016 - 10/2002
3	Cerebral Hemorrhage 08/2005 - 04/2002
2	Autistic Disorder (Autism) 03/2024 - 01/2022
2	Autism Spectrum Disorder 03/2024 - 01/2022
2	Hypertension (High Blood Pressure) 06/2023 - 09/2015
2	Neoplasms (Cancer) 06/2021 - 08/2010
2	Infarction (Infarctions) 01/2020 - 10/2009
2	Brain Injuries (Brain Injury) 12/2015 - 10/2005
2	Intracranial Hemorrhages (Intracranial Hemorrhage) 02/2012 - 01/2011
2	Arteriosclerosis 07/2011 - 03/2009
2	Gastroesophageal Reflux (GERD) 04/2011 - 07/2009
2	Hyperplasia 09/2005 - 09/2005
1	Neuroinflammatory Diseases 03/2024
1	Myocardial Infarction 03/2023
1	Thrombotic Stroke 03/2023
1	Fibrosis (Cirrhosis) 10/2022
1	Non-alcoholic Fatty Liver Disease 10/2022
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 07/2022
1	Hypoglycemia (Reactive Hypoglycemia) 06/2022
1	Hemangioma (Angioma) 06/2022
1	Hypotension (Low Blood Pressure) 06/2022
1	Bradycardia 06/2022
1	Intracranial Embolism 01/2022
1	Hyperthyroidism 06/2021
1	Thyroid Nodule (Nodule, Thyroid) 06/2021
1	Dental Caries (Decay, Dental) 05/2018

Drug/Important Bio-Agent (IBA)

8	Tissue Plasminogen Activator (Alteplase)FDA Link 01/2016 - 06/2002
7	Matrix Metalloproteinases (MMPs)IBA 01/2016 - 02/2002
5	Neuroprotective AgentsIBA 10/2009 - 02/2003
4	CollagenIBA 01/2024 - 09/2011
4	Fibrinolytic Agents (Antithrombotic Agents)IBA 01/2011 - 04/2002
3	CytokinesIBA 03/2024 - 10/2005
3	Carrier Proteins (Binding Protein)IBA 01/2024 - 09/2011
3	Pancreatic Elastase (Elastase)IBA 06/2023 - 09/2015
3	Apolipoproteins E (ApoE)IBA 12/2021 - 01/2017
3	Matrix Metalloproteinase 9 (Gelatinase B)IBA 05/2018 - 04/2004
3	LipidsIBA 04/2018 - 11/2014
3	Proton Pump InhibitorsIBA 04/2017 - 07/2009
3	LigandsIBA 01/2015 - 09/2005
3	Heparin (Liquaemin)FDA LinkGeneric 08/2005 - 04/2002
2	Oxytocin (Pitocin)FDA LinkGeneric 03/2024 - 01/2022
2	SaltsIBA 06/2023 - 01/2018
2	Desoxycorticosterone (Deoxycorticosterone)IBA 06/2023 - 01/2018
2	Acetates (Acetic Acid Esters)FDA Link 06/2023 - 01/2018
2	PlasminogenIBA 10/2022 - 12/2021
2	CholesterolIBA 07/2022 - 02/2002
2	oxidized low density lipoproteinIBA 12/2021 - 01/2018
2	LDL CholesterolIBA 04/2018 - 01/2018
2	ApolipoproteinsIBA 04/2018 - 01/2018
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2018 - 04/2017
2	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 01/2018 - 11/2005
2	LDL Receptors (LDL Receptor)IBA 01/2018 - 12/2015
2	Coloring Agents (Dyes)IBA 09/2015 - 11/2014
2	Cytochrome P-450 CYP2C19IBA 08/2014 - 07/2009
2	sitafloxacinIBA 03/2014 - 01/2014
2	Poly(ADP-ribose) Polymerase InhibitorsIBA 10/2005 - 11/2004
2	P-SelectinIBA 09/2005 - 09/2005
2	Rose BengalIBA 04/2003 - 04/2002
1	8-Hydroxy-2'-DeoxyguanosineIBA 06/2023
1	IronIBA 06/2023
1	Dietary IronIBA 06/2023
1	Clopidogrel (Plavix)FDA Link 03/2023
1	Prasugrel Hydrochloride FDA Link 03/2023
1	Tranexamic Acid (AMCA)FDA Link 10/2022
1	Streptozocin (Streptozotocin)FDA Link 10/2022
1	Tyrosine Kinase InhibitorsIBA 07/2022
1	Dasatinib (BMS 354825)FDA Link 07/2022
1	Propranolol (Inderal)FDA LinkGeneric 06/2022
1	Lipoproteins (Lipoprotein)IBA 12/2021
1	Cyclic AMP (AMP, Cyclic)IBA 06/2021
1	Codon (Codons)IBA 06/2021
1	Thyroxine (Levothyroxine)FDA LinkGeneric 06/2021
1	Clarithromycin (Biaxin)FDA LinkGeneric 01/2020
1	Anti-Infective Agents (Microbicides)IBA 01/2020
1	Bromodeoxyuridine (BrdU)IBA 01/2020

Therapy/Procedure

9	Therapeutics 03/2024 - 10/2002
5	Thrombolytic Therapy 01/2022 - 04/2002
2	Aftercare (After-Treatment) 03/2023 - 07/2009
2	Intravenous Injections 01/2016 - 11/2014
2	Transplantation 08/2010 - 03/2009
1	Lasers (Laser) 01/2022
1	Thrombectomy 01/2022
1	Thyroidectomy 06/2021
1	Exercise Therapy (Therapy, Exercise) 01/2020